AmCAD-CA is a software device designed for analyzing digital cytological images. Considering morphology and chromatology, AmCAD-CA can be used to identify cytological features such as nuclear-cytoplasm ratio, anisokaryosis, molding, pseudoinclusion, etc. The numeric quantified and visualized cytology features may be used to assist clinical interpretation of diseases. In particular, a computer-aided diagnosis (CAD) model has been built and included in the software to assist diagnoses of thyroid neoplasms.